Catalogue Number : 2144674

Description

25-hydroxy Cholesterol is a dietary cholesterol derivative with a side chain substituted oxysterol that is capable of triggering the activation of many cholesterol molecules. It has been reported to activate ABCA1 signaling, atherosclerosis modulation,  induces apoptosis in human cell lines through caspases activation  bcl-2 downregulation. 25-hydroxy Cholesterol is immunomodulating  is capable of suppressing macrophage differentiation from monocytes.

Additional Information

CAS Number

2140-46-7

Purity:

≥98%

Storage Conditions:

Product should be kept at-20°C.

References:

Peng, S. K., Taylor, C. B., Hill, J. C., & Morin, R. J. (1985). Cholesterol oxidation derivatives  arterial endothelial damage. Atherosclerosis, 54(2), 121-133.

Erickson, S. K., Matsui, S. M., Shrewsbury, M. A., Cooper, A. D., & Gould, R. G. (1978). Effects of 25-hydroxycholesterol on rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in vivo, in perfused liver,  in hepatocytes. Journal of Biological Chemistry, 253(12), 4159-4164.

Aupeix, K., Weltin, D., Mejia, J. E., Christ, M., Marchal, J., Freyssinet, J. M., & Bischoff, P. (1995). Oxysterol-induced apoptosis in human monocytic cell lines. Immunobiology, 194(4), 415-428.