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591239-68-8 詢問(wèn)

ZINC05007751((Z)-4-Methyl-2,6-dioxo-5-((5-phenylfuran-2-yl)methylene)-1,2,5,6-tetrahydropyridine-3-carbonitrile)

CAS: 591239-68-8

化學(xué)式: C18H12N2O3

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中文名	ZINC05007751
英文名	(Z)-4-Methyl-2,6-dioxo-5-((5-phenylfuran-2-yl)methylene)-1,2,5,6-tetrahydropyridine-3-carbonitrile
別名	ZINC05007751游離態(tài)
英文別名	ZINC05007751 NEK6 inibitor 8 NEK6 inhibitor 8 3-Pyridinecarbonitrile, 1,2,5,6-tetrahydro-4-methyl-2,6-dioxo-5-[(5-phenyl-2-furanyl)methylene]- (Z)-4-Methyl-2,6-dioxo-5-((5-phenylfuran-2-yl)methylene)-1,2,5,6-tetrahydropyridine-3-carbonitrile (5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile
CAS	591239-68-8
化學(xué)式	C18H12N2O3
分子量	304.3
溶解度	溶于DMSO
存儲(chǔ)條件	-20℃
產(chǎn)品用途	ZINC05007751 是一種有效的 NIMA 相關(guān)激酶 NEK6 抑制劑，IC50 為 3.4 μM。ZINC05007751 對(duì)一組人類(lèi)癌細(xì)胞系顯示出抗增殖活性，并且在 BRCA2 突變的卵巢癌細(xì)胞系中顯示出與順鉑和紫杉醇的協(xié)同效應(yīng)。ZINC05007751 對(duì) NEK1 和 NEK6 具有很強(qiáng)的選擇性，但對(duì) NEK2、NEK7 和 NEK9 沒(méi)有明顯的活性。
參考資料 展開(kāi)查看	[1]. De Donato M, et al. Identification and antitumor activity of a novel inhibitor of the NIMA-related kinase NEK6. Sci Rep. 2018;8(1):16047. Published 2018 Oct 30.

591239-68-8 - 配置溶液濃度參考

	1mg	5mg	10mg
1 mM	3.286 ml	16.431 ml	32.862 ml
5 mM	0.657 ml	3.286 ml	6.572 ml
10 mM	0.329 ml	1.643 ml	3.286 ml
5 mM	0.066 ml	0.329 ml	0.657 ml

最后更新：2024-01-02 23:10:35