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298-93-1 詢問(wèn)

噻唑藍(lán)溴化四唑(MTT)

CAS: 298-93-1;2348-71-2

化學(xué)式: C18H16BrN5S

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中文名	噻唑藍(lán)溴化四唑
英文名	MTT
別名	噻唑藍(lán) 噻唑蘭 噻唑藍(lán)溴化四唑 溴化噻唑藍(lán)四氮唑 噻唑四唑藍(lán)溴化鹽 3-(4,5-二甲基噻唑-2)-2,5-二苯基四氮唑溴鹽 3-(4,5-二甲基-2-噻唑)-2,5-二苯基四氮唑溴鹽 3-(4,5-二甲基-2-噻唑)-2,5-二苯基溴化四氮唑 3-(4,5-二甲基-2-噻唑基)-2,5-二苯基四氮唑溴化物 溴化-3-(4,5-二甲基-2-噻唑基)-2,5-二苯基四氮唑 3-(4,5-二甲基-2-噻唑)-2,5-二苯基四氮唑溴鹽(MTT) 3-(4,5-二甲基-2-噻唑基)-2,5-二苯基-2H-四氮唑溴化物 3-(4,5-二甲基-2-噻唑基)-2,5-二苯基-2H-四氮唑鎓溴化物 3-(4,5-二甲基-2-噻唑)-2,5-二苯基溴化四氮唑噻唑藍(lán),噻唑蘭,溴化噻唑藍(lán)四氮唑
英文別名	MTT MTT (1.11714) Thiazolyl Blue METHYLTHIAZOLETETRAZOLIUM Thiazolyl Blue tetrazolium bromide 3-(4,5-Dimethyl-2-Thiazolyl)-2,5-Diphenyl 3-(4,5-Dimethyl-2-thizolyl)-2,5-diphenyltertazolium bromide 3,[4,5-Dimethylthiazol-2-YL]-2,5-DIPHENYLTETRAZOLIUM BROMIDE 2,5-diphenyl-3-(4,5-dimethylthiazol-2-yl)tetrazolium Bromide 3-(4,5-Dimethylthiazolyl-2)-2,5-DIPHENYL TETRAZOLIUM BROMIDE 3-(4,5-Dimethyl-2-THIAZOLYL)-2,5-DIPHENYLTETRAZOLIUM BROMIDE 3-(4,5-Dimethylthiazol-2-YL)-2,5-DIPHYL-2 H-TETRAZOLIUM BROMIDE 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2h-tetrazoliumbromide 2,5-diphenyl-3-(4,5-dimethylthiazol-2-yl)-2h-tetrazolium Bromide 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide 3-(4,5-DIMETHYLITHIAZOLYL-2)-2,5-DIPHENYL MONOTETRAZOLIUM BROMIDE 3-(4,5-Dimethyl-2-THIAZOL-2-YL)-2,5-DIPHENYL-2H-TETRAZOLIUM BROMIDE 2-(4,5-Dimethyl-2-thiazolyl)-3,5-diphenyl-2H-tetrazol-3-ium Bromide 3-(4,5-dimethyl-1,3-thiazol-2-yl)-2,5-diphenyl-2H-tetrazol-3-ium bromide 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-2,3-dihydro-1H-tetrazol-3-ium bromide 2-(4,5-Dimethylthiazol-2-yl)-3,5-diphenyl-2,3-dihydro-1H-tetrazol-3-ium bromide 3-(4,5-dimethyl-1,3-thiazol-2-yl)-2,5-diphenyl-2,3-dihydro-1H-tetrazol-1-ium bromide
CAS	298-93-1 2348-71-2
EINECS	206-069-5
化學(xué)式	C18H16BrN5S
分子量	414.32
InChI	InChI=1/C18H17N5S.BrH/c1-13-14(2)24-18(19-13)23-21-17(15-9-5-3-6-10-15)20-22(23)16-11-7-4-8-12-16;/h3-12H,1-2H3,(H,20,21);1H
InChIKey	AZKSAVLVSZKNRD-UHFFFAOYSA-M
密度	1.4886 (estimate)
熔點(diǎn)	195 °C (dec.) (lit.)
水溶性	Slightly soluble.Clear yellow solution at 5mg in 1ml of water on vortexing
溶解度	甲醇: 5mg/ml，澄清
存儲(chǔ)條件	2-8°C
穩(wěn)定性	吸濕性
敏感性	Light Sensitive
外觀	粉末
顏色	Yellow to orange
最大波長(zhǎng)(λmax)	['378 nm, 242 nm']
BRN	3825277
MDL號(hào)	MFCD00011964
體外研究	Thiazolyl Blue (MTT) is used in conjunction with rhodamine B to measure mitochondrial membrane potential. Thiazolyl Blue-formazan is generated in mitochondria acts as a fluorescence quencher for rhodamine that distributes across membranes of viable cells according to membrane potential. In the absence of mPMS, cellular reduction of Thiazolyl Blue is strong. Thiazolyl Blue is membrane-impermeable when incorporated into large unilamellar liposomes, and therefore it is taken up by cells via endocytosis.
危險(xiǎn)品標(biāo)志	Xi - 刺激性物品 T - 有毒物品 Xn - 有害物品
風(fēng)險(xiǎn)術(shù)語(yǔ)	R46 - 可能引起遺傳性基因損害。 R68 - 可能有不可逆后果的危險(xiǎn)。 R36/37/38 - 刺激眼睛、呼吸系統(tǒng)和皮膚。
安全術(shù)語(yǔ)	S22 - 切勿吸入粉塵。 S24/25 - 避免與皮膚和眼睛接觸。 S53 - 避免接觸，使用前須獲得特別指示說(shuō)明。 S45 - 若發(fā)生事故或感不適，立即就醫(yī)(可能的話，出示其標(biāo)簽)。 S36/37 - 穿戴適當(dāng)?shù)姆雷o(hù)服和手套。 S26 - 不慎與眼睛接觸后，請(qǐng)立即用大量清水沖洗并征求醫(yī)生意見(jiàn)。
WGK Germany	3
RTECS	XF8060000
FLUKA BRAND F CODES	3-8-10
TSCA	Yes
海關(guān)編號(hào)	29341000
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298-93-1 - 介紹

常用于基于MTT檢測(cè)方法的細(xì)胞活力、細(xì)胞增殖或細(xì)胞毒性檢測(cè)。因?yàn)镸TT具有正電荷，它可以穿過(guò)細(xì)胞膜并被線粒體還原形成紫色甲臜染料。溶解MTT甲臜染料需要使用有機(jī)溶劑。脫氫酶的檢測(cè)，生化研究中酶活力的測(cè)定，測(cè)定NADH2、NADPH2和心肌黃酶(Diaphorase)。最后更新：2022-10-16 17:24:22

298-93-1 - 簡(jiǎn)介

噻唑藍(lán)溴化四唑是一種有機(jī)合成化合物。它是一種深藍(lán)色的晶體固體，不溶于水，溶于有機(jī)溶劑如甲醇、氯仿等。

噻唑藍(lán)溴化四唑主要用于熒光探針、DNA染料等方面。它可以通過(guò)與DNA中G-C堿基對(duì)特異性結(jié)合而發(fā)光，并用于DNA凝膠電泳、PCR擴(kuò)增等實(shí)驗(yàn)室技術(shù)中。

制備噻唑藍(lán)溴化四唑一般采用化學(xué)合成方法。具體做法是將2-甲基-4-硝基苯胺與硫氰酸鈉反應(yīng)得到2-甲基-4-硫代噻唑，然后與偶氮二乙酸酯、高氯酸銨反應(yīng)生成中間體，最后通過(guò)甲苯磺酰氯和溴反應(yīng)制得噻唑藍(lán)溴化四唑。

噻唑藍(lán)溴化四唑在使用時(shí)需注意安全。它具有一定的毒性和刺激性，需要避免直接接觸皮膚或吸入。在操作過(guò)程中應(yīng)佩戴防護(hù)手套、眼鏡和口罩等個(gè)人防護(hù)用具，并確保通風(fēng)良好。另外，噻唑藍(lán)溴化四唑應(yīng)儲(chǔ)存在干燥、陰涼處，遠(yuǎn)離火源和氧化劑。最后更新：2024-04-10 22:29:15