應(yīng)用；   A useful matrix support for affinity chromatography  

CAS號碼:   355012-90-7  

分子量:   468.52(anhydrous)  

分子式:   C₂₅H₂₉FN₄O₄•₁/₂H₂O  

* 參考分析證明 大量特定數(shù)據(jù) (包括水 含量).

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(Carboxymethyloximino)spiperone, Hemihydrate is used as an affinity chromatography matrix support for the purification of the D₂-dopamine receptor. Spiperone (sc-204293) is an 5-HT_2A serotonin and selective D₂-like dopamine receptor antagonist (K_i values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D₂, D₃, D₄, D₁ and D₅ receptors respectively). Although the well known role of Spiperone in research studies indicates it acts as an antagonist of either 5-HT₂ or D₂ receptors, Spiperone has also been reported to act through a protein tyrosine kinase-coupled phospholipase C-dependent pathway. Spiperone was observed to act independent of either 5-HT₂ or D₂ receptors as reported In a study investigating the role of Spiperone and Ca²⁺ activated Cl^- (CaCC) in human cystic fibrosis (CF) airway epithelial cell monolayers in vitro.

參考文獻

1. Senogles, S.E., et al. 1986. Biochemistry. 25: 749-753. PMID: 2938619
2. Hoyer, D., et al. 1994. Pharmacol. Rev. 46: 157-203. PMID: 7938165
3. Seeman, P. and Van Tol, H.H. 1994. Trends Pharmacol. Sci. 15: 264-270. PMID: 7940991
4. Liang, L., et al. 2011. PLoS ONE. 6: e21991. PMID: 21765932

外觀 :

Oil

保存 :

Store at -20° C

僅供科研使用。不可用于診斷或治療。  

SMILES :

OC(=O)CO\N=C(/CCCN1CCC2(CC1)N(CNC2=O)C1=CC=CC=C1)C1=CC=C(F)C=C1