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| Description | |
|---|---|
| Overview | A low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that it is freely filtered by the glomerular membrane. Serum levels of cystatin C can be used as a specific and sensitive marker of glomerular filtration rate. Protects organisms against undesirable proteolysis by endogenous or exogenous enzymes. Thought to be linked to many disease processes including Alzheimer’s disease, hereditary cerebral hemorrhage, and lung cancer. |
| Catalogue Number | 240896 |
| Brand Family | Calbiochem? |
| Synonyms | Post γ-globulin |
| References | |
|---|---|
| References | Hall, A., et al. 1998. Biochemistry 37, 4071. Peloille, S., et al. 1997. Eur. J. Biochem. 244, 140. Cimerman, N., et al. 1996. Biol. Chem. Hoppe Seyler 377, 19. Tenstad, O., et al. 1996. Scand. J. Clin. Lab. Invest. 56, 409. |
| Product Information | |
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| ATP Competitive | N |
| Form | Solid |
| Formulation | Lyophilized from 20 mM NH?HCO?. |
| Reversible | N |
| Applications |
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| Biological Information | |
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| Primary Target | Cysteine protease |
| Purity | ≥95% by SDS-PAGE |
| Source | Prepared from the urine of patients with chronic renal tubular proteinuria that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. |
| Physicochemical Information | |
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| Cell permeable | N |
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| Ship Code | Ambient Temperature Only |
| Toxicity | Standard Handling |
| Storage | +2°C to +8°C |
| Do not freeze | Ok to freeze |
| Special Instructions | Following reconstitution, store in the refrigerator at 4°C. Stock solutions are stable for up to 2 month when stored at -20°C. |
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