羥基伊曲康唑(伊曲康唑代謝物)

生物活性靶點體外研究體內(nèi)研究 用途與合成方法 MSDS 羥基伊曲康唑(伊曲康唑代謝物)價格(試劑級) 上下游產(chǎn)品信息

中文名稱	羥基伊曲康唑(伊曲康唑代謝物)
中文同義詞	伊曲康唑雜質(zhì)1;依曲康唑雜質(zhì);伊曲康唑代謝物;伊曲康唑2-羥基代謝物;羥基伊曲康唑;羥基伊曲康唑(伊曲康唑代謝物);伊曲康唑雜質(zhì)8;2H6]-羥基曲康唑
英文名稱	HYDROXY ITRACONAZOLE
英文同義詞	HYDROXY ITRACONAZOLE;3H-1,2,4-Triazol-3-one, 4-4-4-4-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-;4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-3H-1,2,4-triazol-3-one;R 63373;Itraconazole Impurity 8(Hydroxy Itraconazole);4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-Methylpropyl)-;Itraconazole 2-Hydroxy Metabolite;Itraconazole metabolite Hydroxy Itraconazole
CAS號	112559-91-8
分子式	C35H38Cl2N8O5
分子量	721.63
EINECS號
相關(guān)類別	對照品-雜質(zhì)對照品;臨床檢測標(biāo)準(zhǔn)物質(zhì);Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Various Metabolites and Impurities;Isotooe labelled metabolites;metabolites;Isotopically Labeled Pharmaceutical Reference Standard
Mol文件	112559-91-8.mol
結(jié)構(gòu)式

羥基伊曲康唑(伊曲康唑代謝物) 性質(zhì)

羥基伊曲康唑(伊曲康唑代謝物) 用途與合成方法

生物活性

Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) 是 Itraconazole (ITZ) 的活性代謝物，Itraconazole 是一種三唑類抗真菌劑。

靶點

Antifungal

體外研究

Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ). Although Hydroxy Itraconazole is also reported to have antifungal activity in vitro, its pharmacokinetics in humans has been studied less than that of ITZ. ITZ and Hydroxy Itraconazole have a triazole ring and inhibit CYP3A. Their half-lives can be extended by 26-60% with repeated administration compared to single administration.

體內(nèi)研究

The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view.

安全信息

MSDS信息

羥基伊曲康唑(伊曲康唑代謝物) 價格(試劑級)

羥基伊曲康唑(伊曲康唑代謝物) 上下游產(chǎn)品信息