維生素 B12A

生物活性體外研究體內(nèi)研究 用途與合成方法 MSDS 維生素 B12A價(jià)格(試劑級(jí)) 上下游產(chǎn)品信息

中文名稱	維生素 B12A
中文同義詞	羥鈷胺單鹽酸鹽;化合物 T13731;維生素 B12雜質(zhì)13 (維生素 B12 EP 雜質(zhì)H 鹽酸鹽);維生素 B12 EP雜質(zhì)H 鹽酸鹽
英文名稱	hydroxocobalamin monohydrochloride
英文同義詞	Einecs 261-772-4;Cobinamide hydroxide dihydrogen phosphate (ester), inner salt 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole monohydrochloride;hydroxocobalamin monohydrochloride;Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3), monohydrochloride;Cobinamide,Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with(5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3), hydrochloride (1:1);Vitamin B12a monohydrochloride;Vitamin B12a hydrochloride >=96% (UV), >=96% (HPLC);Cyanocobalamin Impurity 13 (Cyanocobalamin EP Impurity H Hydrochloride)
CAS號(hào)	59461-30-2
分子式	C62H89ClCoN13O15P
分子量	1381.83
EINECS號(hào)	261-772-4
相關(guān)類別
Mol文件	59461-30-2.mol
結(jié)構(gòu)式

維生素 B12A 性質(zhì)

維生素 B12A 用途與合成方法

生物活性

Hydroxocobalamin monohydrochloride (Vitamin B12a monohydrochloride) 是一種可注射的天然維生素 B12，具有良好的不良反應(yīng)特征，可作為維生素 B12 缺乏癥 (包括惡性貧血) 的膳食補(bǔ)充劑。

體外研究

The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide and hydroxocobalamin attenuates vascular responses to NO     in vitro    .

體內(nèi)研究

Treatment with hydroxocobalamin before or after giving LPS attenuates LPS-induced hypotension and increases in plasma RNI and enhances LPS-induced urinary excretion of RNI. Hydroxocobalamin (20 mg/kg i.p.) given to Swiss-Webster mice 30 min before giving LPS (16 mg/kg i.p.) decreases the 24-hr mortality of LPS from 80 to 50% and the 36- and 96-hr mortality from 100 to 60% (hydroxocobalamin).  
 More than 60% of the mice administered 35 mg/kg (0.63 mmol/kg) of NaSH (LD90) survive (at 24 h) when hydroxocobalamin (0.25 mmol/kg) is given after NaSH administration whereas less than 15% of the mice survive without hydroxocobalamin. Hydroxocobalamin (50–100 μM) or cobalt (50–100 μM) also preventes hepatocyte cytotoxicity induced by NaSH (500 μM). Furthermore, adding hydroxocobalamin 60 min later than NaSH still shows some protective activity.

安全信息

MSDS信息

維生素 B12A 價(jià)格(試劑級(jí))

維生素 B12A 上下游產(chǎn)品信息