木蘭脂素

生物活性靶點體外研究 用途與合成方法 MSDS 木蘭脂素價格(試劑級) 上下游產(chǎn)品信息

中文名稱	木蘭脂素
中文同義詞	望春花素;木蘭脂素;木蘭脂素, 來源于辛夷;木蘭脂素(標(biāo)準(zhǔn)品);木蘭脂素(分析標(biāo)準(zhǔn)品);木蘭苷;木蘭脂素對照品;(1S,3AR,4S,6AR)-1-(3,4-二甲氧基苯基)-4-(3,4,5-三甲氧基苯基)六氫呋喃并[3,4-C]呋喃
英文名稱	magnolin
英文同義詞	1H,3H-Furo[3,4-c]furan, 1-(3,4-dimethoxyphenyl);Medioresinol dimethyl ether;tetrahydro-4-(3,4,5-trimethoxyphenyl)-,(1S,3aR,4S,6aR)-;Magnolin;Maglin;Magnolin, 98%, from Magnolia liliflora Desr.;(1S,3aR,4S,6aR)-1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan;1H,3H-Furo[3,4-c]furan, 1-(3,4-dimethoxyphenyl)tetrahydro-4-(3,4,5-trimethoxyphenyl)-, (1S,3aR,4S,6aR)-
CAS號	31008-18-1
分子式	C23H28O7
分子量	416.46
EINECS號	202-110-6
相關(guān)類別	中藥標(biāo)準(zhǔn)品;中藥對照品;分析標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品;植物提取物;對照品;標(biāo)準(zhǔn)品-對照品;對照品-中藥對照品;木脂素;分析試劑-對照品;標(biāo)準(zhǔn)品，對照品;化工原料;Miscellaneous Natural Products
Mol文件	31008-18-1.mol
結(jié)構(gòu)式

木蘭脂素 性質(zhì)

木蘭脂素 用途與合成方法

生物活性

Magnolin 是 Magnolia flos (Shin-Yi) 的主要成分，靶向作用于ERK1 和 ERK2，IC50s 分別為 87 nM 和 16.5 nM，從而抑制Ras/ERKs/RSK2信號通路。

靶點

體外研究

Magnolin is a natural compound abundantly found in     Magnolia    flos, which has been traditionally used in oriental medicine to treat headaches, nasal congestion and anti-inflammatory reactions. Magnolin targets the active pockets of ERK1 and ERK2, which are important signaling molecules in cancer cell metastasis. Magnolin inhibits NF-κB transactivation activity by suppressing the ERKs/RSK2 signaling pathway. Magnolin inhibits the production of tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) by inhibiting extracellular signal-regulated kinases (ERKs), which are key signaling molecules in the regulation of cell proliferation, transformation and cancer cell metastasis. JB6 Cl41 cell migration enhanced by EGF treatment is dramatically suppressed by Magnolin treatment in a dose-dependent manner. Magnolin inhibits ERK1/2/RSK2 signaling-mediated IκBα phosphorylation at Ser32, resulting in the inhibition of NF-κB activation and cell migration.

化學(xué)性質(zhì) 

白色結(jié)晶粉末，溶于氯仿，來源于望春花，木蘭科辛夷Magnolia denudata Desr的花蕾。

用途 

木蘭脂素具有抗過敏，抗炎，降壓，抑菌的作用。

用途 

用于含量測定/鑒定/藥理實驗等

安全信息

MSDS信息

木蘭脂素 價格(試劑級)

木蘭脂素 上下游產(chǎn)品信息