維生素E醋酸酯

生物活性體外研究體內(nèi)研究 用途與合成方法 MSDS 維生素E醋酸酯價(jià)格(試劑級) 上下游產(chǎn)品信息

中文名稱	維生素E醋酸酯
中文同義詞	氨基甘嘌呤霉素;嘌呤霉素氨基核苷;博羅霉素氨基核苷;氨基核酸嘌呤酶素;氨基核苷嘌呤霉素;3'-氨基-3'-脫氧-N,N-二甲基腺苷;(2R,3R,4S,5S)-4-氨基-2-(6-(二甲基氨基)-9H-嘌呤-9-基)-5-(羥甲基)四氫呋喃-3-醇;PUROMYCIN AMINONUCLEOSIDE 氨基核苷嘌呤霉素 NSC 3056
英文名稱	PUROMYCIN AMINONUCLEOSIDE
英文同義詞	3’-amino-3’-deoxy-n,n-dimethyl-adenosin;6-(dimethylamino)-9-(3-amino-3-deoxy-beta-d-ribofuranosyl)purine;9-(3-amino-3-deoxy-beta-d-ribofuranosyl)-6-(dimethylamino)-9h-purine;aminonucleoside;aminonucleosidepuromycin;stylomycinaminonucleoside;PUROMYCIN AMINONUCLEOSIDE;6-DIMETHYLAMIN-9-[3'-AMINO-3'DEOXYRIBOSYL]-PURINE
CAS號(hào)	58-60-6
分子式	C12H18N6O3
分子量	294.31
EINECS號(hào)	200-388-3
相關(guān)類別	微生物代謝物;抗生素;生化試劑;醫(yī)藥原料
Mol文件	58-60-6.mol
結(jié)構(gòu)式

維生素E醋酸酯 性質(zhì)

維生素E醋酸酯 用途與合成方法

生物活性

Puromycin aminonucleoside (NSC 3056)  是一種氨基核苷類抗生素，為嘌呤霉素類似物。Puromycin aminonucleoside 誘導(dǎo)細(xì)胞凋亡 (apoptosis)。Puromycin aminonucleoside 可逆抑制二肽基肽酶 (dipeptidyl peptidase II) 和胞漿丙氨酸氨基肽酶。嘌呤霉素氨基核苷是抗生素嘌呤霉素的氨基核苷部分。

體外研究

Puromycin aminonucleoside (NSC 3056) (30 μg/mL) markedly increases p53 protein levels in podocytes. Puromycin aminonucleoside (NSC 3056)-induced podocyte apoptosis is p53 dependent. Puromycin aminonucleoside (NSC 3056) induces podocyte apoptosis in a time-dependent manner. The IC     ₅₀    values for PMAT-expressing and vector-transfected cells are 48.9 and 122.1 μM, respectively, suggesting expression of PMAT-enhanced cell sensitivity to Puromycin aminonucleoside. Puromycin aminonucleoside (NSC 3056) (250 μM) is toxic to both PMAT-expressing and vector-transfected cells. Puromycin aminonucleoside (NSC 3056) uptake in PMAT-expressing cells is fourfold higher at pH 6.6 than that at pH 7.4.

體內(nèi)研究

The number of podocytes per glomerulus is 95.5±17.6 in the control rats, 90.7 on Day 4 in Puromycin aminonucleoside (NSC 3056) (8 mg/100 g, i.v.)-treated nephrosis rats. The amount of nephrin per glomerulus in control rats is 1.02±0.11 fmol and those in Puromycin aminonucleoside (NSC 3056) nephrosis rats are reduced to 0.46±0.06 fmol and 0.35±0.04 fmol on Day 4 and Day 7. The nephrin amount per podocyte is significantly decreased association with the development of proteinuria in Puromycin aminonucleoside (NSC 3056) nephrosis rats. Rats given Puromycin aminonucleoside (NSC 3056) (100 mg/kg, s.c.) gain less weight and their serum creatinine levels are higher than the control rats.

類別

有毒物品

可燃性危險(xiǎn)特性

可燃;燃燒產(chǎn)生有毒氮氧化物煙霧

儲(chǔ)運(yùn)特性

庫房通風(fēng)低溫干燥

滅火劑

干粉、泡沫、砂土, 二氧化碳, 霧狀水

安全信息

MSDS信息

維生素E醋酸酯 價(jià)格(試劑級)

維生素E醋酸酯 上下游產(chǎn)品信息

上游原料

3'-Azido-3'-deoxy-N6,N6-dimethyladenosine