HOECHST 34580

生物活性靶點體外研究 用途與合成方法 MSDS HOECHST 34580價格(試劑級) 上下游產(chǎn)品信息

中文名稱	HOECHST 34580
中文同義詞	赫斯特34580游離;N,N-二甲基-4-(5-(4-甲基哌嗪-1-基)-1H,1'H-[2,5'-聯(lián)苯并[D]咪唑]-2'-基)苯胺;化合物HOECHST 34580;NO34580 熒光染料;N,N-二甲基-4-(5-(4-甲基哌嗪-1-基)-1H,1'H-[2,5'-聯(lián)苯并[D]咪唑]-2'-基)苯胺
英文名稱	HOECHST 34580
英文同義詞	HOECHST 34580;HOE 34580;ProaMine;2,50-bibenzimidazole, 20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-;Benzenamine, N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-;Hoechst 34580 (HOE 34580);N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline;N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline
CAS號	23555-00-2
分子式	C27H29N7
分子量	451.57
EINECS號
相關(guān)類別	Benzimidazole
Mol文件	23555-00-2.mol
結(jié)構(gòu)式

HOECHST 34580 性質(zhì)

HOECHST 34580 用途與合成方法

生物活性

Hoechst 34580 (HOE 34580) 是一種具有細胞滲透性的藍色熒光染料，用于染色DNA和細胞核。Hoechst 34580 也是一種治療阿爾茨海默病的良好候選者，通過抑制 amyloid beta (Aβ) 的形成，其IC50值為0.86 μM。

靶點

體外研究

Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC     ₅₀    of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC     ₅₀    ) is examined. The IC     ₅₀    is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580.

安全信息

MSDS信息

HOECHST 34580 價格(試劑級)

HOECHST 34580 上下游產(chǎn)品信息